Potassium Hydroxide → HCID 14347235、化合物

HRID 1110495ノート

反応式

HRID 1110495 の反応式
C([O:3][C:4](=[O:21])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C.[OH-].[K+]>CO>[C:9]1([C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:21])=[O:3])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 14196832Ethyl (2E)-5,5-diphenyl-2,4-pentadienoate

生成物 1

HCID 14347235HCID 14347235、化合物収率 86.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of (E)-5,5-diphenyl-2,4-pentadieneoic acid ethyl ester (15 g) in methanol (80 mL) was treated with a 4N Potassium hydroxide solution (20 mL) and the mixture was stirred at reflux for 45 minutes. Most of the methanol was removed under reduced pressure, then the residual solution was poured over ice containing 3N hydrochloric acid (30 mL). The resulting solid was collected by filtration washed with water and dried. Crystallization of the crude material from 2-propanol furnished 11.7 g of (E)-5,5-diphenyl-2,4-pentadienoic acid mp 193°-194° C. Recrystallization from the same solvent did not affect the melting Point. Anal. Calculated for C17H14O2 : C, 81.57: H, 5.63 Found: C, 81.43; H. 5.81.

後処理

  1. temperatureat reflux for 45 minutes
  2. customMost of the methanol was removed under reduced pressure
  3. additionthe residual solution was poured over ice containing 3N hydrochloric acid (30 mL)
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with water
  6. customdried
  7. customCrystallization of the crude material from 2-propanol

出典と根拠

ORDレコード
ord-71f78bd4e5084a6a9bdf8452aafef985
出典データセット
uspto-grants-1990_12
特許番号
US04975438

反応ノート

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