HCID 13785667、化合物 → 5-Amino-4-chloro-o-cresol hydrochloride

HRID 1110646ノート

反応式

HRID 1110646 の反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[H][H]>C(O)C.[Ni]>[ClH:1].[CH3:12][C:4]1[CH:3]=[C:2]([Cl:1])[C:7]([NH2:8])=[CH:6][C:5]=1[OH:11]

参加物

5

反応物 2

HCID 13785667HCID 13785667、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 221538465-Amino-4-chloro-o-cresol hydrochloride

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

5 g of 4-chloro-2-methyl-5-nitrophenol were dissolved in 200 ml of ethanol and, after addition of 0.5 g of Raney nickel, the resulting solution was catalytically hydrogenated. When the uptake of hydrogen stopped, the catalyst was separated off by filtration and the filtrate acidified with dilute hydrochloric acid. Concentration to dryness produced light beige crystals melting at 198° C. (with decomposition).

後処理

  1. customthe catalyst was separated off by filtration
  2. concentrationConcentration to dryness

出典と根拠

ORDレコード
ord-aa05f674da744910ab5daf8dcd0502e0
出典データセット
uspto-grants-1990_12
特許番号
US04976742

反応ノート

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