Tris(hydroxymethyl)aminomethane → Prinomide Tromethamine

HRID 1110851ノート

反応式

HRID 1110851 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9]#[N:10].[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24]>C(O)C>[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24].[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:9]#[N:10]

参加物

4

反応物 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 60352Prinomide

生成物 1

HCID 3033812Prinomide Tromethamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 13.85 g of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile in 350 ml of ethanol is added 6.1 g of tromethamine. The suspension is heated until solution is obtained and the volume is reduced to about 75 ml. The solution is cooled to crystallize the product, the salt is collected, washed with ethanol/ether and dried to yield 1-methyl-beta oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile tromethamine (1:1) salt of example 1.

後処理

  1. temperatureThe suspension is heated until solution
  2. customis obtained
  3. temperatureThe solution is cooled
  4. customto crystallize the product
  5. customthe salt is collected
  6. washwashed with ethanol/ether
  7. customdried

出典と根拠

ORDレコード
ord-2f36f66d134640aa9594dbfdce49ba90
出典データセット
uspto-grants-1990_12
特許番号
US04977181

反応ノート

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