Ammonia → HCID 178510518、化合物

HRID 1110876ノート

反応式

HRID 1110876 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[CH:17][N:18](C)C)[C:9]2=[O:21])[CH:5]=[CH:6][CH:7]=1.N>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[CH:17][NH2:18])[C:9]2=[O:21])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 537196081-(3-Chlorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone

生成物 1

HCID 178510518HCID 178510518、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Title product of Example A3 (0.3 g, 1 mmole) was stirred with 10 ml of ethanol for 3 minutes and the mixture then perfused with NH3 for 1 hour at 25°, stirred an additional 16 hours, and concentrated to an oil, which crystallized on standing in vacuo. Trituration with pentane gave purified title product, 0.25 g, m.p. 141°-143°.

後処理

  1. concentrationconcentrated to an oil, which
  2. customcrystallized
  3. customTrituration with pentane gave
  4. custompurified title product, 0.25 g, m.p. 141°-143°

出典と根拠

ORDレコード
ord-8709ffacc30e43e3b78b7212bcbc37f0
出典データセット
uspto-grants-1990_12
特許番号
US04977178

反応ノート

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