2-Butene, 1-bromo- → Ethyl hydantoate

HRID 1111005ノート

反応式

HRID 1111005 の反応式
ON=CC1C=CC([NH:10][C:11]([NH:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:12])=CC=1.C[O-].[Na+].C(Br)C=CC>O>[CH2:18]([O:17][C:15]([CH2:14][NH:13][C:11](=[O:12])[NH2:10])=[O:16])[CH3:19]

参加物

5

反応物 3

HCID 1224142-Butene, 1-bromo-HCID 10942334Sodium MethoxideHCID 867443964-(hydroxyiminomethyl)phenyl-N'-ethoxycarbonylmethylurea

生成物 1

HCID 222535Ethyl hydantoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of N-[4-(hydroxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the corresponding N-[4-crotyloxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea.

後処理

  1. customfalls to about 20° C
  2. extractionextracted with diethyl ether The ether solution
  3. dry with materialis dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed by rotary evaporator

出典と根拠

ORDレコード
ord-2f143d14ef1843ab9fe27bc5bb02b4dc
出典データセット
uspto-grants-1990_12
特許番号
US04977272

反応ノート

読み込み中…