2-Butene, 1-bromo- → N'-n-propoxycarbonylmethylurea
反応式
ON=CC1C=CC([NH:10][C:11]([NH:13][CH2:14][C:15]([O:17][CH2:18][CH2:19][CH3:20])=[O:16])=[O:12])=CC=1.C[O-].[Na+].C(Br)C=CC>O>[CH2:18]([O:17][C:15]([CH2:14][NH:13][C:11](=[O:12])[NH2:10])=[O:16])[CH2:19][CH3:20]参加物
5
実験手順
A solution of N-[4-(hydroxyiminomethyl)phenyl]-N'-n-propoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether. The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the corresponding N-[4-crotyloxyiminomethyl)phenyl]-N'-n-propoxycarbonylmethylurea.
後処理
- customfalls to about 20° C
- extractionextracted with diethyl ether
- dry with materialThe ether solution is dried over MgSO4
- filtrationfiltered
- customthe solvent is removed by rotary evaporator
出典と根拠
- ORDレコード
- ord-f525c65173264ad0a2ed900b37418fc2
- 出典データセット
- uspto-grants-1990_12
- 特許番号
- US04977272
反応ノート
読み込み中…