Hydrochloric Acid → N-(allyloxycarbonyl)glycine methyl ester

HRID 1111050ノート

反応式

HRID 1111050 の反応式
[CH2:1]([O:4][C:5]([NH:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6])[CH:2]=[CH2:3].Cl.[C:13](=O)(O)[O-].[Na+]>CO>[CH3:13][O:10][C:9](=[O:11])[CH2:8][NH:7][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[O:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 11964402N-[(allyloxy)carbonyl]glycine

生成物 1

HCID 22154858N-(allyloxycarbonyl)glycine methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 0.06 mol of N-(allyloxycarbonyl)glycine, prepared as described by F. Guibe, O. Dangles, and G. Balavione in Tetrahedron Letters, 1986, 27, 2365-2368, and 0.066 mol of HCl in 100 mL of CH3OH is stirred at reflux for 8 hours. The solution is then cooled and treated with 0.066 mol of sodium bicarbonate. The solvent is removed by rotary evaporator, and the residue is dissolved in diethyl ether, filtered, dried over MgSO4, and filtered. The solvent is removed by rotary evaporator to give N-(allyloxycarbonyl)glycine methyl ester.

後処理

  1. temperatureat reflux for 8 hours
  2. temperatureThe solution is then cooled
  3. customThe solvent is removed by rotary evaporator
  4. dissolutionthe residue is dissolved in diethyl ether
  5. filtrationfiltered
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. customThe solvent is removed by rotary evaporator

出典と根拠

ORDレコード
ord-c6d3ef9add384eb29b0cd1b055b59e8a
出典データセット
uspto-grants-1990_12
特許番号
US04977272

反応ノート

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