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1,1'-Carbonyldiimidazole → 9-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | N-Desmethyl-N(4)-desoxychlordiazepoxide | HCID 165626 | — |
| 反応物 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 生成物 | 9-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one | HCID 22153726 | — |
反応手順
In the manner given in Example 16, carbonyldiimidazole, 4-dimethylamino-butyn-2-oic acid and 2-amino-7-chloro-5-phenyl-3H-1,4-benzodiazepine was stirred in tetrahydrofuran-dimethylformamide to give 9-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04978753 |
| 出典データセット | uspto-grants-1990_12 |
| ORD ID | ord-2af7079530fa421d8f6674cac9a77390 |
| 出典メモ | uspto-grants-1990_12 |