Boron tribromide → HCID 22152290、化合物

HRID 1111331ノート

反応式

HRID 1111331 の反応式
[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[CH:6][C:7]([O:13]C)=[C:8]([CH:11]=[O:12])[CH:9]=2)[CH2:4][CH2:3]1.B(Br)(Br)Br>C(Cl)Cl>[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[CH:6][C:7]([OH:13])=[C:8]([CH:11]=[O:12])[CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 22152297HCID 22152297、化合物

生成物 1

HCID 22152290HCID 22152290、化合物収率 85.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4.25 g (20.8 mmol) of 1,1-dimethyl-5-methoxyindan-6-carboxaldehyde in 25 ml of methylene chloride and cooled in an ice water bath was added 22 ml (22.0 mmol, 1M in methylene chloride) of boron tribromide. After stirring for 1 h, the reaction mixture was poured into 100 ml of ice water The organic phase was dried and evaporated. The residue was chromatographed on silica gel (50 g) using hexane as eluent There was obtained 3.37 g (17.7 mmol, 85%) of 1,1-dimethyl-5-hydroxyindan-6-carboxaldehyde as a white solid; mp 40°-40.5° C.

後処理

  1. customwas dried
  2. customevaporated
  3. customThe residue was chromatographed on silica gel (50 g)

出典と根拠

ORDレコード
ord-aaf92925cf1549f3a19c1dd0a9aa3679
出典データセット
uspto-grants-1990_12
特許番号
US04980352

反応ノート

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