Triethylamine → Ethyl 11-(2-benzoyl-4-chlorobenzenesulphonamido)undecanoate

HRID 1111353ノート

反応式

HRID 1111353 の反応式
C(N(CC)CC)C.Cl.[NH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].[C:25]([C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[S:40](Cl)(=[O:42])=[O:41])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[C:25]([C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[S:40]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:42])=[O:41])(=[O:32])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 27566002-benzoyl-4-chloro-benzenesulfonyl ChlorideHCID 13192101Ethyl 11-aminoundecanoate hydrochloride

生成物 1

HCID 22152233Ethyl 11-(2-benzoyl-4-chlorobenzenesulphonamido)undecanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

7 ml of anhydrous triethylamine are added to 5.3 g of ethyl 11-aminoundecanoate hydrochloride in 30 ml of anhydrous methylene chloride and, after stirring for one hour at ambient temperature, 6.3 g of 2-benzoyl-4-chlorobenzenesulphonyl chloride are added dropwise. After stirring for 12 hours, the reaction medium is evaporated to dryness under vacuum, taken up with water and extracted with ethyl acetate. The organic phase which is washed with water until the washings are free of Cl- ions is dried over sodium sulphate and evaporated to dryness under vacuum.

後処理

  1. stirringAfter stirring for 12 hours
  2. customthe reaction medium is evaporated to dryness under vacuum
  3. extractionextracted with ethyl acetate
  4. washThe organic phase which is washed with water until the washings
  5. dry with materialis dried over sodium sulphate
  6. customevaporated to dryness under vacuum

出典と根拠

ORDレコード
ord-0e1e648f1e614fd5b802cf141116c059
出典データセット
uspto-grants-1990_12
特許番号
US04980349

反応ノート

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