Phosgene → HCID 53997918、化合物
反応式
[NH2:1][C:2]1[S:3][C:4]([I:7])=[CH:5][N:6]=1.[C:8](Cl)(Cl)=[O:9]>C(OCC)(=O)C>[I:7][C:4]1[S:3][C:2]([N:1]=[C:8]=[O:9])=[N:6][CH:5]=1参加物
4
実験手順
2-Amino-5-iodothiazole (19.0 grams) and a saturated solution of phosgene in ethyl acetate (200 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux with stirring for a period of about 3 hours. After this time the reaction mixture is cooled and filtered to recover the desired product 5-iodothiazol-2-yl isocyanate dimer.
後処理
- customequipped with a mechanical stirrer
- temperaturethermometer and reflux condenser
- temperatureThe reaction mixture is heated
- temperatureat reflux
- temperatureAfter this time the reaction mixture is cooled
- filtrationfiltered
- customto recover the desired product 5-iodothiazol-2-yl isocyanate dimer
出典と根拠
- ORDレコード
- ord-f12ed2a7b92349a99306a4186862a27e
- 出典データセット
- uspto-grants-1978_10
- 特許番号
- US04118390
反応ノート
読み込み中…