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Trityl chloride → Bifonazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trityl chloride | HCID 6456 | — |
| 反応物 | 4-(Chlorophenylmethyl)-1,1'-biphenyl | HCID 111006 | — |
| 反応物 | TMS-Imidazole | HCID 14420972 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Bifonazole | HCID 2378 | 52.1% |
反応手順
167 g (0.6 mol) of biphenyl-4-yl-phenyl-chloromethane [alternatively named as diphenyl-phenyl-chloromethane or as α-(biphenyl-4-yl)benzyl chloride] and 92 g (0.66 mol) of trimethylsilylimidazole, dissolved in 500 ml of acetonitrile, are heated under reflux for 15 hours. After distilling off the solvent, the crystalline residue is purified by recrystallization from ethyl acetate. 97 g (52% of theory) of (biphenyl-4-yl)-imidazol-1-yl-phenylmethane of melting point 142° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04118487 |
| 出典データセット | uspto-grants-1978_10 |
| ORD ID | ord-5bffc8abda5f4c0ba78b60f58d66befa |
| 出典メモ | uspto-grants-1978_10 |