Cyclopropylamine → HCID 15581949、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([NH2:10])=[S:9].[CH:11]1(N)[CH2:13][CH2:12]1>O>[CH:11]1([NH:10][C:8](=[S:9])[CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:13][CH2:12]1参加物
4
実験手順
A solution of 7.6 g. (0.05 mole) of 2-(2-pyridyl)thioacetamide in a 40% aqueous solution of cyclopropylamine is refluxed for 45 minutes. After cooling, approximately 30 ml. of water is added. The reaction mixture is extracted three times with chloroform. The extracts are combined and dried over magnesium sulfate. The solvent is removed under reduced pressure. The residue is recrystallized twice from ethyl acetate/hexane to give N-cyclopropyl-2-(2-pyridyl)thioacetamide.
後処理
- temperatureAfter cooling
- extractionThe reaction mixture is extracted three times with chloroform
- dry with materialdried over magnesium sulfate
- customThe solvent is removed under reduced pressure
- customThe residue is recrystallized twice from ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-b8e087a1b0034817b66b7ed1f0a7b354
- 出典データセット
- uspto-grants-1978_10
- 特許番号
- US04118567
反応ノート
読み込み中…