Potassium Hydroxide → 3-Hydroxy-3-methyl-n-nonanoic acid

HRID 1112001

反応式

HRID 1112001 の反応式
C([O:3][C:4](=[O:15])[CH2:5][C:6]([OH:14])([CH3:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])C.[OH-].[K+]>C(O)C>[OH:14][C:6]([CH3:13])([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:5][C:4]([OH:15])=[O:3]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 225736Ethyl 3-hydroxy-3-methylnonanoate

生成物 1

HCID 131768443-Hydroxy-3-methyl-n-nonanoic acid収率 83.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl-3-hydroxy-3-methyl-n-nonanoate (25 g) was refluxed for 3 hours with a 10% solution of potassium hydroxide in dry ethanol (210 ml). The ethanol was evaporated in vacuo and the residue was treated with water (100 ml). The aqueous solution was washed with ether then was acidified (ice-bath cooling) with dilute hydrochloric acid. The oil that separated was extracted into ether. The ether solution was washed with brine then was dried over magnesium sulphate and evaporated to give a light yellow oil. This was vacuum distilled to yield 3-hydroxy-3-methyl-n-nonanoic acid as a clear syrup (18.1g).

後処理

  1. customThe ethanol was evaporated in vacuo
  2. additionthe residue was treated with water (100 ml)
  3. washThe aqueous solution was washed with ether
  4. temperature(ice-bath cooling) with dilute hydrochloric acid
  5. customThe oil that separated
  6. extractionwas extracted into ether
  7. washThe ether solution was washed with brine
  8. dry with materialthen was dried over magnesium sulphate
  9. customevaporated
  10. customto give a light yellow oil
  11. distillationThis was vacuum distilled

出典と根拠

ORDレコード
ord-b2b229b1603b4a2c8ccbe8eac74c430d
出典データセット
uspto-grants-1978_10
特許番号
US04119726

関連ノート

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