Hydrochloric Acid → HCID 178474231、化合物

HRID 1112322ノート

反応式

HRID 1112322 の反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7](Br)[N+:6]=1[O-:12])(=[O:3])[CH3:2].[SH-:13].[Na+].Cl>C(O)C>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([SH:13])[N+:6]=1[O-:12])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 178474109HCID 178474109、化合物

生成物 1

HCID 178474231HCID 178474231、化合物収率 79%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2 gms (0.0087 mole) of 2-acetamido-6-bromopyridine-1-oxide was suspended in 35 ml (0.035 mole) of 1M aqueous sodium hydrosulfide and 30 ml of ethanol and agitated at 60° C. for 5 hours and at room temperature one night. Concentrated hydrochloric acid was added dropwise to the cold yellow solution and the precipitated solid filtered, giving a 79% yield of 2-acetamido-6-mercaptopyridine-1-oxide. This impure product was purified by recrystallization from 2-propanol and hot filtration to remove a small amount of contaminating sulfur to give pale yellow crystals, m.p.=172.8°-173.5° C.

後処理

  1. filtrationthe precipitated solid filtered

出典と根拠

ORDレコード
ord-0fcaf14ee736481ea2e52c1b33a357dc
出典データセット
uspto-grants-1978_10
特許番号
US04122085

反応ノート

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