Benzylamine → 1-Benzyl-3-phenylurea

HRID 1112332

反応式

HRID 1112332 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([NH:15][C:16](OC2C(O)=C(C3C=CC=CC=3)S(=O)(=O)C=2C2C=CC=CC=2)=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(OCC)(=O)C>[CH2:1]([NH:8][C:16]([NH:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 227636553-(Phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide

生成物 1

HCID 2803631-Benzyl-3-phenylurea

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

540 mg of benzylamine are added to 2.1 g of 3-(N-phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide in 20 ml of ethyl acetate. The solution is boiled under reflux for 1 hour and then washed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution. The wash liquors are extracted with ethyl acetate and the combined organic phases are dried over magnesium sulfate. After evaporating the filtrate, the crystalline residue is recrystallized from dilute ethanol.

後処理

  1. temperatureunder reflux for 1 hour
  2. washwashed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution
  3. extractionThe wash liquors are extracted with ethyl acetate
  4. dry with materialthe combined organic phases are dried over magnesium sulfate
  5. customAfter evaporating the filtrate
  6. customthe crystalline residue is recrystallized from dilute ethanol

出典と根拠

ORDレコード
ord-195cfb6f7ac3451089078aa7bd2aced2
出典データセット
uspto-grants-1978_10
特許番号
US04122090

関連ノート

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