Triethylamine → 2-Isopropoxy-[N-methyl-N-(4-tert-butylphenylthiosulfenyl)carbamoyloxy]benzene

HRID 1112408ノート

反応式

HRID 1112408 の反応式
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:3])[CH3:2].[CH3:12][N:13]([S:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:21][CH:20]=1)[C:14](F)=[O:15].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][C:14](=[O:15])[N:13]([CH3:12])[S:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([CH3:26])([CH3:28])[CH3:27])=[CH:21][CH:20]=1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 209492-IsopropoxyphenolHCID 23333006N-Methyl-N(4-t-Butylphenylthiosulfenyl) Carbamoyl Fluoride

生成物 1

HCID 227640382-Isopropoxy-[N-methyl-N-(4-tert-butylphenylthiosulfenyl)carbamoyloxy]benzene収率 23.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 4.0 g (0.026 m) of 2-isopropoxyphenol and 7.11 g (0.026 m) of N-methyl-N-(p-tert-butylphenylthiosulfenyl)carbamoyl fluoride in 75 ml of toluene was added 2.63 g (0.026 m) of triethylamine. After stirring for 48 hours the reaction mixture was washed with water and dried over anhydrous MgSO4. The product was purified by dry column chromatography to give 2.5g of a white solid. m.p. 84°-85° C.

後処理

  1. washwas washed with water
  2. dry with materialdried over anhydrous MgSO4
  3. customThe product was purified
  4. customby dry column chromatography

出典と根拠

ORDレコード
ord-645733e2950348eb998225ba5213f8e8
出典データセット
uspto-grants-1978_10
特許番号
US04122204

反応ノート

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