Hexadecanolide → N,N-bis(2-hydroxyethyl)-16-hydroxyhexadecanamide

HRID 1114

反応式

HRID 1114 の反応式
[NH:1]([CH2:5][CH2:6][OH:7])[CH2:2][CH2:3][OH:4].[CH2:8]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][O:18][C:16](=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>C[O-].[Na+].O>[OH:4][CH2:3][CH2:2][N:1]([CH2:5][CH2:6][OH:7])[C:16](=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][OH:18]

参加物

5

反応物 2

HCID 7984HexadecanolideHCID 8113Diethanolamine

生成物 1

HCID 19694613N,N-bis(2-hydroxyethyl)-16-hydroxyhexadecanamide収率 82%

試薬・触媒・溶媒 2

HCID 10942334Sodium Methoxide触媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A 200-ml flask equipped with a stirrer was charged with 16.6 g (158 mmol) of diethanolamine and 20.1 g (79 mmol) of cyclohexadecanolide, to which 0.21 g (3.9 mmol) of sodium methoxide was added. The contents were stirred at 80° C. for 18 hours. After completion of the reaction, water was added, and solids deposited were collected by filtration and recrystallized from methanol, thereby obtaining 23.3 g (yield: 82%) of N,N-bis(2-hydroxyethyl)-16-hydroxyhexadecanamide.

後処理

  1. customA 200-ml flask equipped with a stirrer
  2. additionwas added
  3. additionwas added
  4. filtrationsolids deposited were collected by filtration
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-314181a292b147ec995c4191958340db
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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