化工社化工社 化学情報印刷レポート · 研究参考用
Cyanoacetamide → HCID 178418929、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanoacetamide | HCID 7898 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 生成物 | HCID 178418929 | HCID 178418929 | — |
反応手順
Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094909B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-3a88dd9b299e453abb8cca072f727e81 |
| 出典メモ | uspto-grants-2006_08 |