2-(Methylamino)ethanol → 3-[N-(2-hydroxyethyl)-N-methylamino]-2-hydroxy-1-propyl tetradecanate

HRID 1118

反応式

HRID 1118 の反応式
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].[C:6]([O:21][CH2:22][CH:23]1[O:25][CH2:24]1)(=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>C(O)C>[C:6]([O:21][CH2:22][CH:23]([OH:25])[CH2:24][N:2]([CH2:3][CH2:4][OH:5])[CH3:1])(=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

4

反応物 2

HCID 80162-(Methylamino)ethanolHCID 346148Oxiran-2-ylmethyl tetradecanoate

生成物 1

HCID 867521723-[N-(2-hydroxyethyl)-N-methylamino]-2-hydroxy-1-propyl tetradecanate収率 60.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A 100-ml flask equipped with a stirrer and dropping funnel was charged with 6.01 g (80 mmol) of N-methylethanolamine, 50 ml of ethanol and 22.8 g (80 mmol) of glycidyl tetradecanate, and the contents were stirred at 80° C. for 2 hours. The resultant reaction mixture was concentrated under reduced pressure, and the residue was purified by chromatography on silica gel, thereby obtaining 17.5 g (yield: 60.8%) of the title compound (IIe-2).

後処理

  1. customA 100-ml flask equipped with a stirrer
  2. customThe resultant reaction mixture
  3. concentrationwas concentrated under reduced pressure
  4. customthe residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-a88b93c6dde7436aafafe69ae2775345
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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