Benzyl Bromide → 1-Bromo-4-phenylmethoxybenzene

HRID 11201

反応式

HRID 11201 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CC(C)=O.C(OCC)(=O)C.O>[CH2:15]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

7

反応物 3

HCID 7498Benzyl BromideHCID 78084-BromophenolHCID 11430Potassium Carbonate

生成物 1

HCID 1388351-Bromo-4-phenylmethoxybenzene

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

後処理

  1. temperatureThe reaction was refluxed under nitrogen
  2. temperatureAfter 5–6 hours of reflux
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated to dryness
  6. customto afford a white fluffy powder

出典と根拠

ORDレコード
ord-9c38a67482a74a60b22a9dd04f69b8a7
出典データセット
uspto-grants-2006_08
特許番号
US07097995B2

関連ノート

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