Methyl 1-piperidin-4-ylprolinate → [3-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-1-[4-(2-methoxycarbonylpyrrolidin-1-yl)piperidin-1-yl]-1-oxopropan-2-yl] 4-(2-oxo-4,5-dihydro-1H-1,3-benzodiazepin-3-yl)piperidine-1-carboxylate

反応式

[CH3:39][O:40][C:41](=[O:42])[CH:43]1[N:44]([CH:48]2[CH2:49][CH2:50][NH:51][CH2:52][CH2:53]2)[CH2:45][CH2:46][CH2:47]1.[O:1]=[C:2]1[NH:3][c:4]2[c:5]([cH:35][cH:36][cH:37][cH:38]2)[CH2:6][CH2:7][N:8]1[CH:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][CH:18]([CH2:19][c:20]2[cH:21][c:22]([Cl:31])[c:23]([NH2:30])[c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]2)[C:32](=[O:33])[OH:34])[CH2:13][CH2:14]1>>[O:1]=[C:2]1[NH:3][c:4]2[c:5]([cH:35][cH:36][cH:37][cH:38]2)[CH2:6][CH2:7][N:8]1[CH:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][CH:18]([CH2:19][c:20]2[cH:21][c:22]([Cl:31])[c:23]([NH2:30])[c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]2)[C:32](=[O:34])[N:51]2[CH2:50][CH2:49][CH:48]([N:44]3[CH:43]([C:41]([O:40][CH3:39])=[O:42])[CH2:47][CH2:46][CH2:45]3)[CH2:53][CH2:52]2)[CH2:13][CH2:14]1