Benzylamine → 1-Benzylaminotridecane-2,3-diol

HRID 1121

反応式

HRID 1121 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:9]1[CH:11]([CH:12]([OH:23])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:10]1>O1CCOCC1>[CH2:1]([NH:8][CH2:10][CH:11]([OH:9])[CH:12]([OH:23])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 134206171,2-Epoxy-3-tridecanol

生成物 1

HCID 196946171-Benzylaminotridecane-2,3-diol収率 72%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A 500-ml flask equipped with a stirrer was charged with 107 g (1 mol) of benzylamine, to which a solution of 5.2 g (71 mmol) of 1,2-epoxy-3-tridecanol in 170 ml of dioxane was added dropwise over 2 hours. After completion of the dropping, a reaction was conducted further for 12 hours at 80° C. Dioxane and excess benzylamine were distilled off under reduced pressure. The resultant residue was recrystallized from hexane, thereby obtaining 16.4 g (yield: 72%) of the title compound (IIh-1).

後処理

  1. customA 500-ml flask equipped with a stirrer
  2. additionwas added dropwise over 2 hours
  3. distillationDioxane and excess benzylamine were distilled off under reduced pressure
  4. customThe resultant residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-5b031bc712c84f05b17662207d4f72dd
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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