Methanol → methyl 4-iodo-1H-pyrrole-2-carboxylate
反応式
[I:1][C:2]1[CH:3]=[C:4](C(=O)C(Cl)(Cl)Cl)[NH:5][CH:6]=1.[CH3:13][OH:14].[CH3:15][O-:16].[Na+]>O.C(OCC)C>[I:1][C:2]1[CH:3]=[C:4]([C:13]([O:16][CH3:15])=[O:14])[NH:5][CH:6]=1参加物
6
実験手順
8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.
後処理
- customthe reaction medium evaporated to dryness
- customthe residue obtained
- customThe organic phase was decanted off
- dry with materialdried over magnesium sulfate
- customevaporated
- customThe residue obtained
- customwas triturated in heptane
- filtrationfiltered
- custom4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered
出典と根拠
- ORDレコード
- ord-2f9353d568ba495d9d6fa8a66d2c0875
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723499
反応ノート
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