Methanol → methyl 4-iodo-1H-pyrrole-2-carboxylate

HRID 1128

反応式

HRID 1128 の反応式
[I:1][C:2]1[CH:3]=[C:4](C(=O)C(Cl)(Cl)Cl)[NH:5][CH:6]=1.[CH3:13][OH:14].[CH3:15][O-:16].[Na+]>O.C(OCC)C>[I:1][C:2]1[CH:3]=[C:4]([C:13]([O:16][CH3:15])=[O:14])[NH:5][CH:6]=1

参加物

6

反応物 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 116816022,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethan-1-one

生成物 1

HCID 11673249methyl 4-iodo-1H-pyrrole-2-carboxylate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

後処理

  1. customthe reaction medium evaporated to dryness
  2. customthe residue obtained
  3. customThe organic phase was decanted off
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customThe residue obtained
  7. customwas triturated in heptane
  8. filtrationfiltered
  9. custom4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

出典と根拠

ORDレコード
ord-2f9353d568ba495d9d6fa8a66d2c0875
出典データセット
uspto-grants-1998_03
特許番号
US05723499

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