Cyclohexylamine → N-cyclohexyl-3-nitropyridin-2-amine
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:11]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:11]1([NH:17][C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1参加物
5
実験手順
A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.
後処理
- extractionThe solution is then extracted with 200 ml of ether
- washthe organic phase is washed three times with water
- dry with materialAfter drying over magnesium sulphate
- customthe ether is evaporated off
出典と根拠
- ORDレコード
- ord-bb30373df9eb45569b1a021302201d7c
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07098220B2
反応ノート
読み込み中…