Cyclohexylamine → N-cyclohexyl-3-nitropyridin-2-amine

HRID 11285

反応式

HRID 11285 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:11]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:11]1([NH:17][C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

5

反応物 3

HCID 7965CyclohexylamineHCID 11430Potassium CarbonateHCID 796132-Chloro-3-nitropyridine

生成物 1

HCID 535050N-cyclohexyl-3-nitropyridin-2-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

後処理

  1. extractionThe solution is then extracted with 200 ml of ether
  2. washthe organic phase is washed three times with water
  3. dry with materialAfter drying over magnesium sulphate
  4. customthe ether is evaporated off

出典と根拠

ORDレコード
ord-bb30373df9eb45569b1a021302201d7c
出典データセット
uspto-grants-2006_08
特許番号
US07098220B2

関連ノート

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