化工社化工社 化学情報印刷レポート · 研究参考用
1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-(2',4'-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3',5'-dimethylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 59804 | — |
| 反応物 | 3,5-Dimethylpiperidine | HCID 118259 | — |
| 生成物 | 1-(2',4'-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3',5'-dimethylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid | HCID 10202962 | 43% |
反応手順
The condensation of with 1-(2′,4′-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3,5-dimethylpiperidine in a similar manner as described in example 1 gave the titled product. Yield 43%, m.p 224–26° C., C23H21F3N2O3, m/z 431. (M+1)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098219B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-ed84d5940c3742fc961e388b67925154 |
| 出典メモ | uspto-grants-2006_08 |