4-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-4-chloro-1-ethylpyrazole-3-carboxamide

反応式

[Cl:19][c:20]1[c:21]([C:27](=[O:28])[OH:29])[n:22][n:23]([CH2:25][CH3:26])[cH:24]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:27]([c:21]1[c:20]([Cl:19])[cH:24][n:23]([CH2:25][CH3:26])[n:22]1)=[O:28]

参加物

反応物 2

HCID 5898204-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid

HCID 672347104-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-6H-1,3-oxazin-2-amine

生成物 1

HCID 67233598N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-4-chloro-1-ethylpyrazole-3-carboxamide

出典と根拠

ORDレコード: ord-36bb3e5c3f6d42ca88f241d616eb79af
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…