Phosphorus tribromide → 2-(2-Bromomethylphenylsulfanylmethyl)benzene

HRID 11311

反応式

HRID 11311 の反応式
[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:18]>CCOCC>[Br:18][CH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[S:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 10977293[2-(Benzylsulfanyl)phenyl]methanol

生成物 1

HCID 108808892-(2-Bromomethylphenylsulfanylmethyl)benzene収率 62.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of (2-Benzylsulfanyl)methanol 4 (120 mg, 0.522 mmol) in anhydrous Et2O was cooled to 4° C. A solution of PBr3 (49 μL, 0.52 mmol) in anhydrous Et2O was added dropwise, keeping the temperature below 10° C. The reaction was allowed to warm to ambient temperature and stirred for one hour. The reaction was filtered through silica gel (2.0 g) and washed with Et2O. The filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give 95 mg of the named product as a yellow oil.

後処理

  1. customthe temperature below 10° C
  2. filtrationThe reaction was filtered through silica gel (2.0 g)
  3. washwashed with Et2O
  4. washThe filtrate was washed with H2O saturated aqueous sodium bicarbonate and brine
  5. dry with materialThe organic layer was dried over Na2SO4
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-dae2fd9bf2a242829a417f449efb103f
出典データセット
uspto-grants-2006_08
特許番号
US07098223B2

関連ノート

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