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Phenol → 3-Nitro-2-phenoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 生成物 | 3-Nitro-2-phenoxypyridine | HCID 901896 | — |
反応手順
In step (3) of Reaction Scheme IV a 2-chloro-3-nitropyridine of Formula XXIV is reacted with phenol to provide a 3-nitro-2-phenoxypyridine of Formula XXV. Phenol is reacted with sodium hydride in a suitable solvent such as diglyme or tetrahydrofuran to form the phenoxide. The phenoxide is then reacted at ambient temperature, or optionally at an elevated temperature, with a compound of Formula XXIV.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098221B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8fb2123c92c44b8f9bd0be7e995b3f32 |
| 出典メモ | uspto-grants-2006_08 |