1,1,1-Trimethoxybutane → tert-butyl 4-(6,7-dimethyl-4-phenoxy-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butylcarbamate

HRID 11371

反応式

HRID 11371 の反応式
[NH2:1][C:2]1[C:3]([O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[N:4][C:5]([CH3:22])=[C:6]([CH3:21])[C:7]=1[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17].[C:30](OC)(OC)(OC)[CH2:31][CH2:32][CH3:33]>>[CH3:22][C:5]1[N:4]=[C:3]([O:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:2]2[N:1]=[C:30]([CH2:31][CH2:32][CH3:33])[N:8]([CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[C:7]=2[C:6]=1[CH3:21]

参加物

3

反応物 2

HCID 1235121,1,1-TrimethoxybutaneHCID 12109126Tert-butyl 4-[(3-amino-5,6-dimethyl-2-phenoxypyridin-4-yl)amino]butylcarbamate

生成物 1

HCID 21973824tert-butyl 4-(6,7-dimethyl-4-phenoxy-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butylcarbamate収率 83.1%

実験手順

Part A Using the general method of Example 12 Part E, tert-butyl 4-[(3-amino-5,6-dimethyl-2-phenoxypyridin-4-yl)amino]butylcarbamate (3.41 g, 8.51 mmol) was reacted with trimethyl orthobutyrate (1.50 mL, 9.37 mmol) to provide 3.2 g of crude tert-butyl 4-(6,7-dimethyl-4-phenoxy-2-propyl-1H-imidazo[4,5-c]pyridin-1-yl)butylcarbamate as purplish semisolid. Part B

出典と根拠

ORDレコード
ord-89a7d73081dd4ec88ad2f9bb812ea5b5
出典データセット
uspto-grants-2006_08
特許番号
US07098221B2

関連ノート

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