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HRID 11372作成日：2026年10月25日

trans-2-Phenyl-1-cyclopropanecarbonyl chloride → 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-{[(1R*,2R*)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)ethyl]-1H-imidazo[4,5-c]pyridin-4-amine

https://huagongshe.com/reaction/11372

反応式

関与物質

役割名称HCID仕込み量
反応物trans-2-Phenyl-1-cyclopropanecarbonyl chlorideHCID 13656—
反応物2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amineHCID 12972962—
生成物2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-{[(1R*,2R*)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)ethyl]-1H-imidazo[4,5-c]pyridin-4-amineHCID 20575807—

反応手順

Using the method of Examples 61–75, trans-2-phenyl-1-cyclopropanecarbonyl chloride was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 476.3039.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07098221B2
出典データセットuspto-grants-2006_08
ORD IDord-cc77f4f09e094c4b9162f96456afaacd
出典メモuspto-grants-2006_08