化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → Rac-2-ethoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1h-indol-4-yl]-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole | HCID 9794289 | — |
| 反応物 | Rac-2-ethoxy-3-(1h-indol-4-yl)-propionic acid ethyl ester | HCID 69279879 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Rac-2-ethoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1h-indol-4-yl]-propionic acid ethyl ester | HCID 69280416 | — |
反応手順
In analogy to the procedures described in examples 1 a] and 1 b], rac-2-ethoxy-3-(1H-indol-4-yl)-propionic acid ethyl ester was reacted with 4-chloromethyl-5-methyl-2-phenyl-oxazole in N,N-dimethylformamide in the presence of sodium hydride to yield rac-2-ethoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1H-indol-4-yl]-propionic acid ethyl ester, which was subsequently saponified to yield rac-2-ethoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1H-indol-4-yl]-propionic acid as off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098228B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8f3f4dd495c149d096e60f2e3399d620 |
| 出典メモ | uspto-grants-2006_08 |