化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-(Carbamoylamino)thiophene-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Trichloroacetyl isocyanate | HCID 76400 | — |
| 反応物 | 2-Aminothiophene-3-carboxamide | HCID 699495 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(Carbamoylamino)thiophene-3-carboxamide | HCID 11171402 | — |
反応手順
2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098240B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f0c8411110a14024be0381e63896f360 |
| 出典メモ | uspto-grants-2006_08 |