Water → 2-[(1-Benzothien-4-yloxy)ethyl]morpholine

HRID 11427

反応式

HRID 11427 の反応式
Cl.ClCC[N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[S:11]1[C:15]2=[CH:16][CH:17]=[CH:18][C:19](O)=[C:14]2[CH:13]=[CH:12]1.[C:21](=[O:24])([O-])[O-].[K+].[K+].O.[CH3:28]N(C)C=O>>[S:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[C:19]([O:24][CH2:21][CH2:28][CH:9]3[O:8][CH2:7][CH2:6][NH:5][CH2:10]3)[C:14]=2[CH:13]=[CH:12]1

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 19217Benzo(b)thiophen-4-olHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

生成物 1

HCID 867602232-[(1-Benzothien-4-yloxy)ethyl]morpholine

反応条件

温度
80 °C

実験手順

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

後処理

  1. temperatureAfter cooling
  2. extractionextracted twice with ethyl acetate
  3. washThe combined solvent phase was washed twice with brine
  4. dry with materialdried (magnesium sulphate)
  5. customevaporated

出典と根拠

ORDレコード
ord-2afdbf5b452c4473aa1f7b3a5c5a3a04
出典データセット
uspto-grants-2006_08
特許番号
US07098240B2

関連ノート

読み込み中…