関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4'-Fluoroacetophenone | HCID 9828 | — |
| 反応物 | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| 反応物 | 2-Methylbenzenesulfonic acid hydrate | HCID 12496995 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,4-Bis(4-fluorophenyl)quinoline | HCID 19694816 | — |
反応手順
A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05723573 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-505bc94ed0b24d42b247b9173702273a |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
