3-Fluoroaniline → 6-((3-Fluorophenyl)amino)-5,8-quinoxalinedione
反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2.[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>[Ag-]=O.C(O)C>[F:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH:17][C:10]1[C:9](=[O:12])[C:8]2[N:7]=[CH:6][CH:5]=[N:4][C:3]=2[C:2](=[O:1])[CH:11]=1参加物
5
実験手順
Approximately one gram of 5,8-dihydroxyquinoxaline was dissolved in 100 ml. of 2B ethanol. To the solution were added about 5 g. of freshly prepared silver (I) oxide and about 3 g. of 3-fluoroaniline. The reaction was stirred overnight at room temperature and worked up in the same manner as described in Example 3. Crystallization from ethyl acetate gave about 500 mg. of the title compound.
後処理
- additionTo the solution were added about 5 g
- customCrystallization from ethyl acetate
- customgave about 500 mg
出典と根拠
- ORDレコード
- ord-7171877cfe2b47b1bae01f044166c85b
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04486432
反応ノート
読み込み中…