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1-Butanol → Benzenepropanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Butanol | HCID 263 | — |
| 反応物 | 1,1,2,2-Tetrachloroethane | HCID 6591 | — |
| 反応物 | Chlorine | HCID 24526 | — |
| 反応物 | 2,2-Dichlorobutanal | HCID 11275051 | — |
| 触媒 | N,N-dimethylformamide;hydrochloride | HCID 10920465 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | Benzenepropanol | HCID 31234 | — |
反応手順
n-Butanol and Cl2 were added concurrently to a 100 ml, four necked, round bottomed flask containing ~10 g of DMF/HCl catalyst and 25 ml of 1,1,2,2-tetrachloroethane. The temperature was maintained between 50° and 55° C. by controlling the rates of the addition. Upon completion of the addition, the reaction mixture was shown to contain mainly the product 2,2-dichlorobutyraldehyde by GC and NMR analysis. Similar results were obtained with isobutanol and 3-phenylpropanol. Analysis was in agreement with authentic products by GC, IR and NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04486608 |
| 出典データセット | uspto-grants-1984_12 |
| ORD ID | ord-58577cdad3b14dbdae74e7181a87f133 |
| 出典メモ | uspto-grants-1984_12 |