Hydrazine → HCID 20435928、化合物

HRID 1154032ノート

反応式

HRID 1154032 の反応式
[CH3:1][C:2]([CH2:13][CH2:14][O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][O:17]1)([C:8](OCC)=[O:9])[C:3](OCC)=[O:4].[NH2:22][NH2:23]>>[CH3:1][C:2]1([CH2:13][CH2:14][O:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)[C:8](=[O:9])[NH:23][NH:22][C:3]1=[O:4]

参加物

3

反応物 2

HCID 9321HydrazineHCID 20435998HCID 20435998、化合物

生成物 1

HCID 20435928HCID 20435928、化合物収率 62%

実験手順

A mixture of 120.8 g (0.4 mol) of diethyl 2-methyl-2-[2-(tetrahydro-2-pyranyloxy)ethyl]-propane-1,3-dioate and 150 ml of anhydrous hydrazine was heated under reflux for 64 hours. The excess hydrazine was removed by distillation and the residue was recrystallized from methanol to give 60.28 g (62%) of 4-methyl-4-[2-(tetrahydro-2-pyranyloxy)-ethyl]-pyrazolidine-3,5-dione having a melting point of 179°-180° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 64 hours
  3. customThe excess hydrazine was removed by distillation
  4. customthe residue was recrystallized from methanol

出典と根拠

ORDレコード
ord-6d1dba4ee100425ba9a53fd1dda0cf95
出典データセット
uspto-grants-1984_12
特許番号
US04487929

反応ノート

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