HCID 20435989、化合物 → HCID 20435943、化合物

HRID 1154035ノート

反応式

HRID 1154035 の反応式
[CH3:1][C:2]1([CH2:17][CH2:18][O:19]C2CCCCO2)[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]>Cl.CO>[OH:19][CH2:18][CH2:17][C:2]1([CH3:1])[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]

参加物

4

反応物 1

HCID 20435989HCID 20435989、化合物

生成物 1

HCID 20435943HCID 20435943、化合物収率 97%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of 3.52 g (0.01 mol) of methyl 2,3,5,8-tetrahydro-2-methyl-1,3-dioxo-2[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in 50 ml of 1M hydrochloric acid and 50 ml of methanol was stirred at room temperature for 1.5 hours. The solvent was removed by evaporation in vacuo. The solid residue was taken up in dichloromethane, dried over magnesium sulfate and evaporated to give 2.6 g (97%) of methyl 2,3,5,8-tetrahydro-2-(2-hydroxyethyl)-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate having a melting point of 97°-99° C. (from diethyl ether).

後処理

  1. customThe solvent was removed by evaporation in vacuo
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-4d5f6c5945fa446d9528c516b17a3c9e
出典データセット
uspto-grants-1984_12
特許番号
US04487929

反応ノート

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