2-(4-Chloro-2-butenyl)-1,3-isoindolinedione → N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione

HRID 1154341

反応式

HRID 1154341 の反応式
Cl[CH2:2][CH:3]=[CH:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.[Na]>CN(C)C=O>[N:17]1([CH2:2][CH:3]=[CH:4][CH2:5][N:6]2[C:14](=[O:15])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH:21]=[CH:20][N:19]=[CH:18]1

参加物

4

反応物 2

HCID 27342002-(4-Chloro-2-butenyl)-1,3-isoindolinedioneHCID 57373095Imidazole sodium

生成物 1

HCID 54070864N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 23.5 g. of N-(4-chloro-2-butenyl)-isoindole-1,3(2H)-dione, 11.0 g. of sodium imidazole and 200 ml. of dimethyl formamide was heated on the steam bath for 18 hours and concentrated to remove the solvent; the residue was taken up in methylene chloride, washed with water, dried with magnesium sulfate and again concentrated. The residue was dissolved in hot ethylacetate and allowed to cool and N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione, m.p. 106°-108° C., was obtained.

後処理

  1. additionA mixture of 23.5 g
  2. concentrationconcentrated
  3. customto remove the solvent
  4. washwashed with water
  5. dry with materialdried with magnesium sulfate
  6. concentrationagain concentrated
  7. dissolutionThe residue was dissolved in hot ethylacetate
  8. temperatureto cool

出典と根拠

ORDレコード
ord-f5ef5eafe588410697b3bd75a7663cdd
出典データセット
uspto-grants-1984_12
特許番号
US04489089

関連ノート

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