Hydrogen Peroxide → 6-Chloro-5-fluoroisatoic acid anhydride
反応式
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:13])[C:5](=[O:12])[NH:6]2.S(=O)(=O)(O)[OH:15].OO>C(O)(=O)C>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[NH:6][C:5](=[O:15])[O:12][C:4](=[O:13])[C:3]=12参加物
5
実験手順
7.8 g (0.039 mol) of 4-chloro-5-fluoro-isatin are suspended in 50 ml of 100 percent acetic acid, treated with 0.25 ml of concentrated sulphuric acid and then 4.4 ml (0.043 mol) of 30 percent hydrogen peroxide are added dropwise thereto. The mixture is subsequently heated to 70° for 2.5 hours, then cooled to 10° and filtered. The crude product is recrystallized from acetone/hexane, there being obtained 6-chloro-5-fluoro-isatoic acid anhydride of melting point 275°-278° (decomposition).
後処理
- temperatureThe mixture is subsequently heated to 70° for 2.5 hours
- temperaturecooled to 10°
- filtrationfiltered
- customThe crude product is recrystallized from acetone/hexane, there
出典と根拠
- ORDレコード
- ord-237ba3d8d381429797a0ca0eda6b6169
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04489003
反応ノート
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