Potassium Hydroxide → HCID 21292013、化合物
反応式
[CH3:1][N:2]([CH2:4][C:5]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][NH:15]C=O)[CH:8]=[CH:7][CH:6]=1)[CH3:3].[OH-].[K+]>CO.C(OCC)C>[CH3:1][N:2]([CH2:4][C:5]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][NH2:15])[CH:8]=[CH:7][CH:6]=1)[CH3:3]参加物
5
実験手順
N-[3-(6-dimethylaminomethyl-2-pyridyloxy) propyl]formamide (2.7 g, 0.013 mol) is added to a solution of 85% potassium hydroxide pellets (3.0 g) dissolved in methanol (30 ml) and heated at gentle reflux for 21 hours. The reaction is cooled, diluted with diethyl ether (30 ml), the precipitated salts filtered, and the solvent removed under vacuum. The residue is dissolved in water and the product exhaustively extracted into ethanol/chloroform, dried and evaporated to give 2.1 g of pure product.
後処理
- temperatureheated
- temperatureat gentle reflux for 21 hours
- temperatureThe reaction is cooled
- filtrationthe precipitated salts filtered
- customthe solvent removed under vacuum
- dissolutionThe residue is dissolved in water
- extractionthe product exhaustively extracted into ethanol/chloroform
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-c7ef9001d41a4d17b3b8667409eeed9b
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04490533
反応ノート
読み込み中…