5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178483223、化合物

HRID 1154724ノート

反応式

HRID 1154724 の反応式
CS[C:3]1[C:7]2=[CH:8][S:9][CH:10]=[C:6]2[S:5](=[O:12])(=[O:11])[N:4]=1.[CH3:13][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH2:26])=[CH:19][CH:18]=1)[CH3:15]>C(O)C>[CH3:15][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:24][CH2:25][NH:26][C:3]2[C:7]3=[CH:8][S:9][CH:10]=[C:6]3[S:5](=[O:11])(=[O:12])[N:4]=2)=[CH:19][CH:18]=1)[CH3:13]

参加物

4

反応物 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 13390866HCID 13390866、化合物

生成物 1

HCID 178483223HCID 178483223、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 1.8 g. (0.0082 m.) of 3-(methylthio)thieno[3,4-d]isothiazole-1,1-dioxide in 10 ml. of ethanol is added 1.76 g. (0.0082 m.) of 2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamine with stirring at room temperature. The reaction mixture is heated to reflux and heating is continued for 1.5 hours. At this time the reaction mixture is filtered to remove insoluble material and then evaporated to dryness. The product is purified using a silica gel column with methanol as the eluant. The desired fraction was evaporated to dryness and then triturated with ether to give 120 mg. a white solid with a m.p. 100°-103° C.

後処理

  1. additionTo a suspension of 1.8 g
  2. temperatureThe reaction mixture is heated
  3. temperatureto reflux
  4. temperatureheating
  5. filtrationAt this time the reaction mixture is filtered
  6. customto remove insoluble material
  7. customevaporated to dryness
  8. customThe product is purified
  9. customThe desired fraction was evaporated to dryness
  10. customtriturated with ether
  11. customto give 120 mg

出典と根拠

ORDレコード
ord-33d63e5c425c4842825c98d7812a539a
出典データセット
uspto-grants-1984_12
特許番号
US04490527

反応ノート

読み込み中…