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Pyridine → Phenyl N-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | Benzenamine, 4-(4-(4-methoxyphenyl)-1-piperazinyl)- | HCID 154406 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Phenyl N-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate | HCID 981607 | 61% |
反応手順
A mixture of 6 parts of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine, 3.6 parts of phenyl carbonochloridate, 75 parts of pyridine and 98 parts of dichloromethane is stirred and warmed till all solid enters solution. Stirring is continued for 30 minutes at room temperature. The reaction mixture is poured onto 500 parts of water and 210 parts of 2,2'-oxybispropane are added. The whole is stirred for a while. The precipitated product is filtered off and crystallized from 1-butanol, yielding 5.2 parts (61%) of phenyl{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}carbamate; mp. 204.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04490530 |
| 出典データセット | uspto-grants-1984_12 |
| ORD ID | ord-7e6f83a538334e12bc722ad209304624 |
| 出典メモ | uspto-grants-1984_12 |