化工社化工社 化学情報印刷レポート · 研究参考用
Isobutylamine → 7-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutylamine | HCID 6558 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Chlorobenzylamine | HCID 66036 | — |
| 反応物 | Sodium dithionate | HCID 146045 | — |
| 反応物 | Ethyl 2-cyano-2-(hydroxyimino)acetate | HCID 6399078 | — |
| 反応物 | HCID 178448423 | HCID 178448423 | — |
| 反応物 | 2-Methylthio-4,4-dimethyl-2-imidazoline hydrochloride | HCID 178503443 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 7-amino-2,2-dimethyl-8-(2-methylpropyl)-6-nitroso-3H-imidazo[1,2-a]pyrimidin-5-one | HCID 178448424 | — |
反応手順
6,7-DIHYDRO-4-(2METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE.-- 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04298734 |
| 出典データセット | uspto-grants-1981_11 |
| ORD ID | ord-919ec093ce254ff6b83298a0c56dee4c |
| 出典メモ | uspto-grants-1981_11 |