Ammonia → 1H-Purine, 8-(2,4-dimethoxyphenyl)-

HRID 1155064

反応式

HRID 1155064 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13](O)=O.N>>[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13]1[NH:8][C:7]2[C:2](=[N:3][CH:4]=[N:5][CH:6]=2)[N:1]=1

参加物

4

反応物 3

HCID 222AmmoniaHCID 70522,4-Dimethoxybenzoic acidHCID 837034,5-Diaminopyrimidine

生成物 1

HCID 30599121H-Purine, 8-(2,4-dimethoxyphenyl)-

実験手順

A mixture of 5.5 g of 4,5-diaminopyrimidine and 10.9 g of 2,4-dimethoxy-benzoic acid was triturated in a mortar. The mixture was added to 100 ml of phosphorus oxychloride and refluxed for one hour. The phosphorus oxychloride was decomposed under stirring into water, and the solution obtained was neutralized with ammonia after filtration. The precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3).

後処理

  1. customwas triturated in a mortar
  2. additionThe mixture was added to 100 ml of phosphorus oxychloride
  3. temperaturerefluxed for one hour
  4. customthe solution obtained
  5. filtrationafter filtration
  6. customThe precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3)

出典と根拠

ORDレコード
ord-6a90d463b66a4dcfa829660cb11e8926
出典データセット
uspto-grants-1981_11
特許番号
US04299834

関連ノート

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