1-Bromodecane → 1-Decylpyrrolidin-2-one

HRID 1155104ノート

反応式

HRID 1155104 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17].CC([O-])(C)C.[K+]>CS(C)=O>[CH2:2]([N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

5

反応物 3

HCID 81731-BromodecaneHCID 120252-PyrrolidoneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 1714271-Decylpyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

22.1 g 1-Bromodecane (0.1 mol), 8.5 g (0.1 mol) of 2-pyrrolidone and 11.2 g (0.1 mol) of potassium tert-butylate were stirred in 100 ml of absolute DMSO for one hour. The DMSO was removed under reduced pressure, the residue taken up with diethyl ether, and washed with water (2 times). After drying with anhydrous MgSo4 and evaporating, the residue was distilled in vacuo. A first fraction, boiling between 140° and 147° C./1.2 mm Hg was discarded. The second fraction 17.4 g of pure product, b.p. 148° C./1.2 mm Hg.

後処理

  1. customThe DMSO was removed under reduced pressure
  2. washwashed with water (2 times)
  3. customAfter drying with anhydrous MgSo4
  4. customevaporating
  5. distillationthe residue was distilled in vacuo
  6. customboiling between 140° and 147° C.

出典と根拠

ORDレコード
ord-70989bcb84964edaa37a7e890bb5524a
出典データセット
uspto-grants-1981_11
特許番号
US04299840

反応ノート

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