Dimethylformamide → HCID 20563001、化合物
反応式
N[C:2]1[O:3][C:4]2[CH:14]=[CH:13][C:12]([CH2:15][CH3:16])=[CH:11][C:5]=2[C:6](=[O:10])[C:7]=1C=O.[C:17]([CH2:19][C:20](Cl)=O)#[N:18].C[N:24]([CH3:27])C=O>>[CH2:15]([C:12]1[CH:11]=[C:5]2[C:4]([O:3][C:2]3[CH:20]=[C:19]([C:27]#[N:24])[CH:17]=[N:18][C:7]=3[C:6]2=[O:10])=[CH:14][CH:13]=1)[CH3:16]参加物
4
実験手順
In 40 ml of dimethylformamide was dissolved 1.82 g of 2-amino-6-ethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde, followed by the addition of 3.5 g of cyanoacetyl chloride. The mixture was reacted at 60° C. for 3 hours, with constant stirring. The solvent was then distilled off under reduced pressure and the residue was chromatographed on silica gel. The desired product was recovered from the chloroform eluate and recrystallized from acetonitrile. By the above procedure was obtained 1.03 g of 7-ethyl-3-cyano-1-azaxanthone, m.p. 183°-185° C.