関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1,4-Dihydro-2H-3,1-benzoxazin-2-one | HCID 25786 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Isopropyl Acetate | HCID 7915 | — |
| 生成物 | 2-Aminobenzyl alcohol | HCID 21439 | — |
反応手順
The reaction mixture from Stage A was boiled so as to drive off the isopropyl acetate solvent. A solution of 100 g of sodium hydroxide in 100 ml of water was added to the residue, and the whole was refluxed for 2 hours. After cooling to 45° C., the product was extracted with four 270 ml portions of isopropyl acetate. The isopropyl acetate was then distilled off and the product recrystallized from toluene to give 100 g (63% of theoretical) of 97-98% pure 2-amino-benzyl alcohol; m.p. 83°-83.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04301283 |
|---|
| 出典データセット | uspto-grants-1981_11 |
|---|
| ORD ID | ord-caa27b79386f449a895ea5d3d2f83872 |
|---|
| 出典メモ | uspto-grants-1981_11 |
|---|
