Hydrochloric Acid → 4-(2',4'-Dichlorophenoxy)-alpha-phenoxy-propionic acid isopropyl ester
反応式
[Cl:1][C:2]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:16]=[CH:15][C:8]([O:9][CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1.Cl.[CH:23](O)([CH3:25])[CH3:24]>>[CH:23]([O:12][C:11](=[O:13])[CH:10]([O:9][C:8]1[CH:15]=[CH:16][C:5]([O:4][C:3]2[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:2]=2[Cl:1])=[CH:6][CH:7]=1)[CH3:14])([CH3:25])[CH3:24]参加物
実験手順
55 g of 4-(2',4'-dichlorophenoxy)-α-phenoxy-propionic acid were suspended in 500 ml of isopropanol. While stirring, hydrogen chloride was fed in, whereupon the temperature rose to about 50° C. While the feed of hydrogen chloride was continued, the suspension was refluxed for 5 hours and the reaction mixture was then allowed to stand overnight. After the excess alcohol had been distilled off, the solution was poured on water and then extracted with methylene chloride. The methylene chloride extract was washed with dilute bicarbonate solution and then twice with water and dried over sodium sulfate. After filtration the solution was concentrated and then distilled under greatly reduced pressure. 34 g of 4-(2',4'-dichlorophenoxy)-α-phenoxy-propionic acid isopropyl ester were obtained, boiling point 182°-185° C. under a pressure of 0.04 mm mercury.
後処理
- customrose to about 50° C
- temperaturethe suspension was refluxed for 5 hours
- distillationAfter the excess alcohol had been distilled off
- additionthe solution was poured on water
- extractionextracted with methylene chloride
- extractionThe methylene chloride extract
- washwas washed with dilute bicarbonate solution
- dry with materialtwice with water and dried over sodium sulfate
- filtrationAfter filtration the solution
- concentrationwas concentrated
- distillationdistilled under greatly reduced pressure
出典と根拠
- ORDレコード
- ord-c17e75be8b41469db440fb501cccc021
- 出典データセット
- uspto-grants-1981_11
- 特許番号
- US04301295
反応ノート
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